Words for the hopeless

Futile, pessimistic, cynical, dejected, demoralized, despairing, desperate, despondent, disconsolate, discouraging, downhearted, fatal, forlorn, gone, goner, helpless, ill-fated, shot down, sunk, unfortunate, up the creek, useless and my personal favorite... woebegone.
So far, page 428 is the most exciting page in the thesaurus. On no other page is there such a controversial word as "Hopeless". Apparently, this is the most hotly contested word in the entire thesaurus. Are hopeless people really cynical? Must all the hopeless be goners?
I agree that all the hopeless are without a doubt "up the creek" but I'm just not sold on words like threatening and pessimistic.

In other news, the end of the world is progressing nicely...